Male Infertility


Nutritional and Environmental Considerations

Research has confirmed that male sperm counts are declining.

Both nutritional and environmental factors have been shown to affect spermatogenesis.

Environmental factors that negatively impact spermatogenesis include pesticides, exogenous estrogens, and heavy metals.




Nutritional Adjuncts in Optimizing Fertility

Nutritional and Therapeutic Factors that impact
sperm counts and sperm motility include:

Free Form L-Arginine (5 g to 20 g per day)
Ferulic Acid
Zinc
Selenium
Vitamin B-12
Vitamin C
Vitamin E
Glutathione
Coenzyme Q10

These nutrients and antioxidants have proven benefits in treating male infertility and can be incorporated into a nutritional program.



Encouraging Optimal Sperm Production
and Function


Improving male fertility requires a multi-faceted
therapeutic approach, which includes:

Correcting underlying nutritional imbalances
Identifying harmful environmental and occupational risk factors



Nutritional Adjuncts in the Field of Fertility

Patented Ferulic Acid

ARGRX is backed by a full United States Patent
for Ferulic Acid and L-Arginine

FERULIC ACID

Ferulic Acid has been identified in clinical trials, as having significant positive effects on sperm viability and motility.

The trial focused on the “Effects of FERULIC ACID on human sperm motility, viability, lipid peroxidation, and cyclic nucleotides in fertile and asthenozoospermic infertile individuals.”

“The results showed: in both fertile and infertile spermatozoa, the viability, trans-membrane migration ratio (TMMR) and the levels of intracellular cAMP and cGMP in FERULIC ACID-treated spermatozoa were significantly higher than those of spermatozoa in control groups, while TBA-reactive substances contents in treated spermatozoa were significantly lower than those in control spermatozoa.

The effects of FERULIC ACID on these processes were concentration dependent. These data suggested that FERULIC ACID is beneficial to sperm viability and motility in both fertile and infertile individuals, and that reduction of lipid peroxidative damage to sperm membranes and increase of intracellular cAMP and cGMP may be involved in these benefits.”

Researchers concluded that “It is possible that FERULIC ACID may be used for cure of asthenozoospermic infertility.”

Effects of ferulic acid on fertile and asthenozoospermic infertile human sperm motility, viability, lipid peroxidation, and cyclic nucleotides; Free Radic Biol Med.





FERULIC ACID
Free Radic Biol Med. 1997;22(4):581-6

Effects of ferulic acid on fertile and asthenozoospermic infertile human sperm motility, viability, lipid peroxidation, and cyclic nucleotides


Zheng RL, Zhang H.
Department of Biology, Lanzhou University, P.R. China

The capacity of human sperm fertilization principally depends on sperm motility and membrane integrity. Reactive oxygen species, such as superoxide anion and hydrogen peroxide, are known to impair sperm motility and membrane integrity by inducing membrane lipid peroxidation (LPO).

Ferulic acid (FA), an effective constituent in various medicinal herbs, has recently been shown to scavenge oxygen free radicals and increase the intracellular cAMP and cGMP.

The aim of this study is to investigate the effects of FA on human sperm motility, viability, lipid peroxidation, and cyclic nucleotides in fertile and asthenozoospermic infertile individuals in vitro.

The sperm samples were obtained from 10 fertile volunteers and 10 asthenozoospermic infertile patients. Washed spermatozoa were incubated at 37 degrees C in Ham's F-10 medium with 0, 0.1, 0.2, 0.4, 0.8, or 1.6 mM of FA. Samples were analyzed for viability, determined by eosin-Y dye exclusion method at 0, 1, 2, 3, 5, and 6 h of incubation; motility, determined by the trans-membrane migration method within 2 h of incubation; LPO, determined by thiobarbituric acid (TBA) method at 3 h of incubation and the intracellular cAMP and cGMP, determined, respectively, by 3H-cAMP and 125I-cGMP radioimmunoassay at 3 h of incubation.

The results showed: in both fertile and infertile spermatozoa, the viability, trans-membrane migration ratio (TMMR) and the levels of intracellular cAMP and cGMP in FERULIC ACID-treated spermatozoa were significantly higher than those of spermatozoa in control groups, while TBA-reactive substances contents in treated spermatozoa were significantly lower than those in control spermatozoa.

The effects of FA on these processes were concentration dependent. These data suggested that FA is beneficial to sperm viability and motility in both fertile and infertile individuals, and that reduction of lipid peroxidative damage to sperm membranes and increase of intracellular cAMP and cGMP may be involved in these benefits.

It is possible that FERULIC ACID may be used for cure of asthenozoospermic infertility.


PMID: 9013120 [PubMed - indexed for MEDLINE]

 





 

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